Lose Fat, Not Muscle with Semaglutide
The FDA-approved GLP-1 that changed weight loss medicine—now with physician supervision and DEXA tracking to ensure you're losing fat, not the muscle that keeps your metabolism healthy. Starting at $199/month.
"I lost 87 lbs on GLP-1s—but I also lost muscle. That's why I track every patient's body composition with DEXA."
— Dr. Josh Lindsley, DO, DABOM · Board-Certified Obesity Medicine
What is Semaglutide?
Semaglutide is a GLP-1 receptor agonist—a medication that mimics a hormone your body naturally produces after eating. It works by signaling to your brain that you're full, reducing appetite and food cravings.
Originally developed for type 2 diabetes (as Ozempic®), semaglutide was FDA-approved for weight loss in 2021 under the brand name Wegovy® after clinical trials showed unprecedented results: patients lost an average of 15% of their body weight over 68 weeks.
At Highland Longevity, we combine semaglutide with DEXA body composition scanning and metabolic testing to ensure you're losing fat—not the muscle that keeps your metabolism healthy.
How Semaglutide Works
Semaglutide targets multiple pathways to help you eat less and feel satisfied longer.
Reduces Appetite
Acts on the hypothalamus to decrease hunger signals and increase feelings of fullness after smaller meals.
Slows Digestion
Delays gastric emptying so food stays in your stomach longer, extending satiety between meals.
Reduces Cravings
Decreases "food noise"—the constant thoughts about food that make dieting so difficult.
Clinical Trial Results
The STEP clinical trials established semaglutide as the most effective FDA-approved weight loss medication.
Source: STEP 1 Clinical Trial (N Engl J Med 2021). Results with 2.4mg weekly dose plus lifestyle intervention.
Real Patient Results
This is why we track body composition, not just weight. The scale doesn't tell the whole story.
Verified DEXA scan data from Highland Longevity patient. Individual results may vary.
Dosing Schedule
We start low and increase gradually to minimize side effects and help your body adjust.
Weeks 1-4
Starting dose to assess tolerance
Weeks 5-8
First dose increase
Weeks 9-12
Therapeutic effects begin
Weeks 13-16
Approaching target dose
Week 17+
Full maintenance dose
Side Effects & Safety
Most side effects are mild, temporary, and occur during the dose escalation period.
💊 Common Side Effects
- Nausea (typically improves after 2-4 weeks)
- Diarrhea or constipation
- Decreased appetite (this is the goal)
- Mild stomach discomfort
- Fatigue during dose increases
⚠️ When to Call Your Doctor
- Severe or persistent nausea/vomiting
- Signs of pancreatitis (severe abdominal pain)
- Vision changes
- Rapid heartbeat
- Signs of allergic reaction
Is Semaglutide Right for You?
Semaglutide is FDA-approved for specific patient populations.
✔ Good Candidates
- BMI of 30 or higher (obesity)
- BMI of 27+ with weight-related conditions (high blood pressure, type 2 diabetes, high cholesterol)
- Previous unsuccessful attempts at diet and exercise alone
- Committed to lifestyle changes alongside medication
- Ready for regular physician monitoring
✥ Not Recommended For
- Personal or family history of medullary thyroid cancer
- Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
- History of pancreatitis
- Pregnant or planning to become pregnant
- Currently breastfeeding
Frequently Asked Questions
Clinical trials show an average of 15% body weight loss over 68 weeks. 86% of patients lose at least 5% of their body weight, and over 50% lose 15% or more. Results vary based on individual factors and adherence to lifestyle modifications.
Both contain semaglutide. Wegovy is FDA-approved specifically for weight loss at a 2.4mg dose. Ozempic is approved for type 2 diabetes at lower doses but is often prescribed off-label for weight loss. The medication is identical—only the indication and dosing differ.
Semaglutide is a long-term medication for chronic weight management. Studies show weight loss is maintained at 2+ years with continued treatment. Stopping the medication typically leads to weight regain, which is why we focus on sustainable lifestyle changes alongside medication.
Studies show that stopping semaglutide typically leads to weight regain. This is why we emphasize body composition—preserving muscle mass—and sustainable nutrition habits. Some patients eventually transition off medication; others use it long-term. Your physician will help you decide.
Semaglutide is injected once weekly using a small, thin needle into the abdomen, thigh, or upper arm. Most patients find it nearly painless. We'll teach you the proper injection technique at your first appointment.
Yes—semaglutide was originally developed for type 2 diabetes (Ozempic). It can help with both blood sugar control and weight loss. However, if you're already on diabetes medications, your physician will need to adjust your treatment plan to avoid low blood sugar.
Ready to Start Semaglutide?
Book a free consultation to discuss whether semaglutide is right for you. We'll review your medical history, current medications, and weight loss goals.